Found 14 matching trials
Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of BI 653048 BS H3PO4 Capsule Assessing Endotoxin-induced Inflammatory Response in Healthy Male Subjects PHASE1 The general aim of the current study was to investigate the safety and tole...
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Immunomodulatory Effects of Dexamethasone, Tocilizumab and Anakinra During Experimental Human Endotoxemia PHASE4 The goal of this clinical trial is to investigate the immunomodulatory effe...
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Intensive Care Medicine, Radboud University Nijmegen Medical Centre
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Effect of Lipopolysaccharide on Skeletal Muscle Functions NA The investigators aim to examine how the skeletal muscles of the human volu...
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Queens Medical Centre
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Defibrotide in the Human Endotoxemia Model --- an Exploratory Trial Investigating the Effects and the Mechanisms of Defibrotide PHASE4 Defibrotide is an anti-inflammatory and anti-coagulatory agent approved for...
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Department of Clinical Pharmacology, Medical University of Vienna
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A Clinical Study to Determine the Safety, Tolerability and Effect of RLS-0071 Doses When Given to Healthy Adults After Inhaling LPS PHASE1 This is a Phase 1b, randomized, double-blind, placebo-controlled, dose rang...
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Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM)
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Effect of BIBT 986 Followed by BIBT 986 Given as IV Infusion on Tissue Factor Triggered Coagulation in Healthy Male Volunteers PHASE1 To compare with placebo the anticoagulant activity of three dosages of BIBT...
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Multiple Locations
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Clearance of Antibacterial Agents During Hemoperfusion in Patients With Sepsis N/A One of the significants health problems in the world is sepsis, with the nu...
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N. V. Sklifosovsky Moscow Research Institute of Emergency
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A New Model of Acute Febrile Disease NA The investigators want to establish a new model of acute febrile disease by...
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Institute for Clinical MEdicine
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Effects of Vasopressors on Immune Response PHASE4 Noradrenaline is a catecholamine and the cornerstone treatment for the impr...
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Vorapaxar in the Human Endotoxemia Model PHASE4 Vorapaxar is a recently approved protease activated receptor - 1 (PAR-1) in...
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Department of Clinical Pharmacology, Medical University of Vienna
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